WebApr 18, 2024 · Introducing siRNA into human immune cells by an artificial delivery system continues to be a challenging issue. We previously developed a multifunctional envelope-type nanodevice (MEND) … Web56 Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells . components leading to cytotoxicity or genotoxicity de- pends on its size. Large particles can induce permanent damage to cell membrane via binding with cellular mem-
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WebMay 31, 2024 · Lipid nanoparticles offer many advantages over previous lipid-based nucleic acid delivery systems including: • High nucleic acid encapsulation efficiency and potent transfection • Improved penetration into tissues to deliver therapeutics • Low cytotoxicity and immunogenicity WebOnce they reach target cells, lipid nanoparticles can be internalized by multiple mechanisms, including macropinocytosis and clathrin-mediated and caveolae-mediated endocytosis 10, 17. The... in boolean logic: a + 1
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WebMar 28, 2024 · 3.2. Cytotoxicity of PDA NPs. The cytotoxicity on RAW 264.7, chondrocytes and osteoblasts were detected through CCK- 8 assay. As shown in i of Fig. 3 A, within the concentration range of 0–50 μg/mL, the cytotoxicity of all NPs was minimum with the cell viability above 95%. However, when the concentration was above 100 … WebMar 9, 2024 · Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells Article Full-text available Jan 2013 JBNB Jennifer Mytych Maciej Wnuk View Dextran... WebNanoparticles containing rare-earth metals have been increasingly involved in biological applications for their unique optical properties, like for instance, upconversion luminescence and lower toxicity compared to QDs. 99–109 Many strategies were developed to construct rare-earth-metal-containing nanoparticles. inc rating