Cytoplasmic retention signal

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August undefined, 2024

WebNov 6, 2024 · In this study, we identified that the glycophorin transmembrane domain encoded an ER/Golgi retention signal, which could be counteracted by forward-trafficking signals (i.e., the R18 epitope of GPA/GP.Mur; the cytoplasmic domain of GPA ) … WebThe N- terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not when fused at the C terminus of the extracellular domain of epidermal growth factor receptor, with or without a heterologous cytoplasmic domain.

Stat3 Isoforms, α and β, Demonstrate Distinct ... - ScienceDirect

WebApr 1, 2006 · Wnt signalling, β-Catenin, Nucleo-cytoplasmic shuttling, FRAP Introduction The canonical Wnt signalling pathway is highly conserved throughout the animal kingdom and regulates crucial steps in cell fate decisions, … WebMar 30, 2024 · The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers. Mary K. Ernst Laboratory of Molecular ... suggesting that it may perform the same function in cells when the activating signal is no longer present. Structurally, the human I κ Bα molecule can be divided ... bitwise and \u0026 operator

Nucleocytoplasmic shuttling of signal transducers - Nature

WebThe majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown biological significance. ... DDX3 mutants were created for in vitro evaluation of the mechanism behind nuclear retention of DDX3.Results: DDX3 was present in the nucleus of 35% of colorectal and 48% of breast cancer ... WebJun 20, 2000 · The IRF3 protein has a nuclear export signal (NES) specifying its cytoplasmic retention . Examination of the p48 protein primary amino acid sequence … bitwise apprenticeship

A Cytoplasmic Inhibitor of the JNK Signal Transduction …

Proteasome-mediated cleavage of the Y-box-binding protein 1 …

WebAug 1, 1997 · Although JNK is located in both the cytoplasm and the nucleus of quiescent cells, activation of JNK is associated with accumulation of JNK in the nucleus ( 8 ). … WebJan 21, 2024 · Misfolded and/or unassembled secretory and membrane proteins in the endoplasmic reticulum (ER) may be retro-translocated into the cytoplasm, where they undergo ER-associated degradation, or ERAD. The mechanisms by which misfolded proteins are recognized and degraded through this pathway have been studied … bitwise arithmetic in cWebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote … bitwise arithmetic

"WebOnly a few reports describe potential mechanisms of cytoplasmic retention of p21. In general, the nuclear localization signal (NLS) and the nuclear export signal (NES) motifs are responsible for the active shuttling of proteins between the nucleus and the cytoplasm. " - Cytoplasmic retention signal

Cytoplasmic retention signal

The differential localization of human cyclins A and B is due to …

WebThe ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 … WebJan 9, 1998 · The retrieval signal was found to be functional even when placed at the distal end of the wild-type SIV Env protein with 164 amino acids in the cytoplasmic tail, as shown by the lack of proteolytic processing and lack of …

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WebOct 29, 2024 · Our results also show that Transportin-2 (TNPO2, importin-3) enhances the cytoplasmic localisation of ERα, not as a nuclear export receptor, but rather as a cytoplasmic retention factor, while it ... WebOct 13, 1995 · The ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 contains redundant, complex ER retention signals in its cytoplasmic and N-terminal hydrophobic domains and that the function of the N-terminal signal is context …

WebOct 13, 1995 · The N-terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not … WebNational Center for Biotechnology Information

WebAug 1, 1997 · The JNK signal transduction pathway is activated in response to environmental stress and by the engagement of several classes of cell surface receptors, including cytokine receptors, serpentine receptors, and receptor tyrosine kinases ( 1 ). Genetic studies of Drosophila have demonstrated that JNK is required for early … WebAug 1, 1999 · studies provide evidence for a cytoplasmic targeting/retention signal (CTRS) in MA that is responsible for intracytoplasmic capsid assembly in Type D retroviruses.

WebJun 1, 2024 · Sequential phosphorylation and activation of MST1/2 and LATS1/2 by upstream signals such as high cell density result in phosphorylation-dependent cytoplasmic retention of the transcriptional coactivator YAP and its paralogue TAZ (transcriptional coactivator with PDZ-binding motif).

WebMar 14, 2024 · The retention signal is recognized by specific receptors present in the ER and cis-GA, which retrieve the protein from post-ER compartments and return them to … bitwise applicationWebOct 19, 2005 · Distribution of YB-1 between the nucleus and the cytoplasm is known to be dependent on nuclear targeting and cytoplasmic retention signals located within the C-terminal portion of YB-1. bitwise assignmentWebMar 21, 2008 · We have determined that the molecular basis for this specialized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and sufficient to restrict wild-type hA3G and chimeric constructs to the cytoplasm. bitwise assignment operators in cWebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic … bitwise attentionWebJan 21, 1997 · In human cyclin B1, a cytoplasmic retention signal (CRS) has been identified that is highly conserved among B-type cyclins in higher eukaryotes. The … bitwise bitcoinWebcdc25C is a phosphatase, which activates the mitosis-promoting factor cyclin B1/cdc2 by dephosphorylation, and thus triggers G2/M transition. The activity of cdc25C itself is controlled by phosphoryl bitwise arithmetic cWebCytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. … datearithmetic