Ctcf zinc fingers

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August undefined, 2024

WebJun 23, 2024 · CTCF is a ubiquitous 11 zinc finger (ZF) protein with highly versatile functions: in addition to transcriptional silencing or activating in … WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 did not totally abrogate the DNA-binding ability of CTCF; instead, they selectively blocked binding to some CTCF target sites, but not to others ( 25 ).

IJMS Free Full-Text The Chromatin Architectural Protein CTCF Is ...

WebThese results demonstrate that CTCF activates transcription from the APP promoter and that the activation domain is located on the N-terminal side of the zinc finger domain . A … WebJan 14, 2024 · Furthermore, CTCF–BORIS chimeric constructs provided evidence that, besides the N terminus of CTCF, the first two CTCF zinc fingers, and likely the 3D geometry of CTCF–DNA complexes, are also involved in cohesin retention. Based on this knowledge, we were able to convert BORIS into CTCF with respect to cohesin … simple flying butterfly outline

Anti-CTCF antibody [mAbcam 37477] (ab37477) Abcam

WebJun 5, 2015 · CCCTC-binding factor (CTCF) is an 82-kDa protein with 11 zinc fingers. 1 It was first identified as a transcriptional repressor of the … WebBACKGROUND: CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the ... simple flying british airways

664799 - Gene ResultCtcfl CCCTC-binding factor (zinc …

DNA recognition patterns of the multi-zinc-finger protein CTCF: a ...

WebThe ubiquitously expressed CCCTC-binding factor (CTCF) is a highly conserved transcription factor carrying 11 zinc finger domains involved in multiple DNA sequence-specific recognition [1,2,3].Combinatorial use of zinc fingers is also responsible for CTCF pleiotropic functions including transcriptional activation/repression, insulator activity, and … WebCTCF is a ubiquitous 11 zinc finger (ZF) protein with highly versatile functions. A transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP. raw_input_streamWebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites. simple flying muckrack

"WebThe minimal deleted area (MDA; see inset) affects the CTCF locus including all 11 zinc fingers. (B) Positions of heterozygous point mutations in or near splice acceptor sites (in dark blue) and missense (in light blue), nonsense (in orange), and insertion mutations (in red) in the coding regions of CTCF transcript ENST00000264010. Exon ... " - Ctcf zinc fingers

Ctcf zinc fingers

An exceptionally conserved transcriptional repressor, …

WebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites. WebGel shift assays utilizing successively deleted zinc finger domains indicated that CTCF zinc fingers 2 to 7 were involved in binding to the chicken MYC promoter, while fingers 3 to 11 mediated CTCF binding to the human promoter. This flexibility in zinc finger usage revealed CTCF to be a 'multivalent' transcription factor.

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WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 did not totally abrogate the DNA-binding … WebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites.

WebThe Myc-associated zinc finger protein (MAZ) was identified and characterized as a regulatory protein associated with MYC gene expression (), and independently as a … WebCTCF is a ubiquitous 11 zinc finger (ZF) protein with highly versatile functions. A transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP.

WebFeb 16, 2024 · Silencing CTCF or COL1A1/COL1A3 markedly inhibited cell growth and migration in the metastatic GC cell line BGC823. Collectively, this ECM-related 7-gene … WebBelongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Domain. The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites.

WebMar 19, 2024 · transcriptional repressor CTCF Names 11-zinc finger protein CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of the page Help. NEW Try …

WebOct 27, 2024 · Thus, ZF8 connects CTCF zinc fingers that recognize modules 1-2 and functions as a bridge to span the gap between modules 1 and 2 (Supplementary information, Figure S4). In contrast to ZFs 3-7 and ... raw input valorant redditWebDec 8, 2024 · Ctcfl CCCTC-binding factor (zinc finger protein)-like [ (house mouse)] Gene ID: 664799, updated on 8-Dec-2024. Summary. Enables histone binding activity and … raw input ue4WebJan 8, 2024 · Methods We collated somatic CTCF mutations from cancer genome portals and published studies to determine their nature, frequency, distribution and potential functional impact. We undertook an in-depth examination of 5 CTCF missense zinc finger (ZF) mutations occurring within key intra- and inter-ZF residues. We performed functional … simple flying machinne in minecraft 1.19WebFeb 28, 2024 · In addition CTCF, as an 11 zinc-finger protein, occupies thousands of loci which act as the anchors of intense chromatin interactions, termed CTCF loops. Largely thanks to sequencing-based approaches like Hi-C, and in conjunction with CRISPR-mediated inversion of motifs, it was shown that the orientation of CTCF binding is … simple flying machine mcWeb5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … rawinput unityWebWe have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved … raw input vs inputWebOct 16, 2024 · Our data confirm that a spectrum of loss-, change- and gain-of-function impacts on CTCF zinc fingers are observed in cell growth regulation and gene … raw_input vs input