Birc3 function
WebBIRC3 functions as an E3 ubiquitin ligase, polyubiqiutinating target proteins such as RIP kinases, caspases, TRAF1, and BCL10. Loss of BIRC3 results in a significant impairment of TNFα-mediated NF-κB activation signaling cascades. Product Details Technical data sheet Product Details Isotype Control Purified Rat IgG2a, κ Isotype Ctrl WebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. BIRC3 INFORMATION. Proteini. Full gene name according to HGNC. Baculoviral IAP repeat containing 3. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BIRC3 (API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49)
Birc3 function
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WebApr 10, 2024 · The in-frame internal tandem duplication (ITD) of the FLT3 gene is an important negative prognostic factor in acute myeloid leukemia (AML). FLT3-ITD is constitutive active and partially retained in the endoplasmic reticulum (ER). Recent reports show that 3′UTRs function as scaffolds that can regulate the localization of … WebFunction. Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase …
WebThen, we used BIRC3 gain-of-function (overexpression) and loss-of-function (knockdown) studies to examine the effect of BIRC3 on HCC cell proliferation and invasion. In … WebBIRC3 3ʹ UTRs did not influence BIRC3 protein localization (Figure 1G). Knockdown of the Long BIRC3 3ʹ UTR Isoform to Study the Function of BIRC3-LU in B Cells We next set …
WebApr 8, 2024 · 5.2. Gene Expression Analysis. Our study demonstrated the presence of the BIRC2, BIRC3, and BIRC5 transcripts in all the examined mesenchymal stem cells derived from the umbilical cord Wharton’s jelly (WJSC).. The relationships between the expression level of the examined genes and the pregnant age, method of delivery, selected … WebMay 16, 2024 · Alternative 3' untranslated regions (3' UTRs) are widespread, but their functional roles are largely unknown. We investigated the function of the long BIRC3 3' …
WebMar 14, 2024 · To further explore the function of BIRC3 in pulmonary function, we analyzed the correlation between BIRC3 and pulmonary function. Our results showed …
WebMay 5, 2024 · BIRC3-LU has cancer-promoting functions in CLL. Expression of CXCR4 on the surface of B cells mediates homing of cells to protective bone marrow niches, thus, … incipient lymphomaWebApr 1, 2024 · BIRC3 encodes a ubiquitin ligase, and alternative cleavage and polyadenylation generates short (BIRC3-SU) and long (BIRC3-LU) 3 UTR mRNA isoforms, the latter of which is significantly... incipient osteoarthritisincipient osteomyelitisWebMar 21, 2024 · Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of … inbound flights to charleston wvWebMay 16, 2024 · Both BIRC3-SU and BIRC3-LU can accomplish 3ʹ-UTR-independent functions, such as the cell-intrinsic control of cell death. However, only BIRC3-LU has … incipient moment of your life essayWebMay 19, 2015 · BIRC3 is a member of the BIRC family, and apoptosis regulation is one of the important functions of their encoded proteins [19,20]. Furthermore, BIRC2, BIRC3 and TRAF2 had been identified as critical genes in the activation of NF-κB signaling in TNF pathways . At the same time, BIRC3 was observed to be significantly more up-regulated … incipient plasticityWebMar 29, 2024 · We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein localization or … inbound flights boston